پژوهشگر

همکاران پژوهشگر

چکیده پژوهش

There have been inconsistent reports that Metrnl-like protein, a new adipokine, is associated with the risk of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). A systematic search in PubMed, Scopus, Web of Science, and Google scholar databases were conducted up until 24 November 2020. Ten eligible studies were included in this meta-analysis. The overall results showed that there was no significant association between serum Metrnl levels and risk of T2DM and CAD in patients compared with healthy control (SMD¼ 0.717 and 95%CI 1.572_0.139, p ¼ .1). However, in subgroup analysis, there was a significant association between a BMI 25 and the serum level of Metrnl-like protein (SMD¼ 0.688 and 95%CI 1.348_0.028 p ¼ .041), indicating a potential inverse connection between serum Metrnl and the adiposity. Further well-designed studies are needed to explain the more subtle roles of Metrnl in metabolic disorders like T2DM and CAD.

خلاصه نتایج حاصله

A summary of the detailed process include screening and literature selection of the eligible articles are provided in Figure 1. Based on the inclusion and exclusion criteria, a total of 41 relevant english articles were selected. After assessment the titles and abstracts, 22 article were excluded as unrelated, duplicate and/or animal or cell studies. After review, 19 papers remained for full text evaluation, 9 papers excluded because insufficient data and finally 10 articles were included in the current study for pooling SMD analysis (Chung et al. 2018, Lee et al. 2018, El-Ashmawy et al. 2019, Liu et al. 2019, Wang et al. 2019, Du et al. 2020, Fadaei et al. 2020, Onalan et al. 2020, Wang et al. 2020). One paper included two different groups of patients, patients with CAD and patients with T2DM separately in compare with healthy, thus counted as two studies (Dadmanesh et al. 2018).

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